3D printed alginate-cellulose nanofibers based patches for local curcumin administration.
Carbohydr Polym
; 264: 118026, 2021 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-33910718
ABSTRACT
Alginate and nanocellulose are potential biomaterials to be employed as bioinks for three-dimensional (3D) printing. Alginate-cellulose nanofibers (A-CNF) formulations with CNF amounts up to 5â¯wt% were developed and rheologically characterized to evaluate their printability. Results showed that formulations with less than 3â¯wt% CNF did not present suitable characteristics to ensure shape fidelity after printing. Selected A-CNF bioinks were 3D printed and freeze-dried to obtain porous scaffolds. Morphological and mechanical analysis were performed, showing that CNF contributed to the reinforcement of the scaffolds and modulated their porosity. The applicability for drug delivery was evaluated by the addition of curcumin to printable A-CNF formulations. The curcumin loaded bioinks were successfully 3D printed in patches and the in vitro release tests showed that alginate and CNF played an important role in curcumin stabilization, whereas the CNF content and the disintegration of the scaffold were essential in the release kinetics.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Celulose
/
Curcumina
/
Alginatos
/
Nanofibras
/
Bioimpressão
/
Impressão Tridimensional
Limite:
Humans
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Espanha