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Role of von Willebrand Factor in COVID-19 Associated Coagulopathy.
Mei, Zhen W; van Wijk, Xander M R; Pham, Huy P; Marin, Maximo J.
Afiliação
  • Mei ZW; Department of Pathology and Laboratory Medicine, The University of California, Los Angeles, CA.
  • van Wijk XMR; Department of Pathology, The University of Chicago, Chicago, IL.
  • Pham HP; National Marrow Donor Program, Be the Match Collection Center, Seattle, WA.
  • Marin MJ; Department of Pathology and Laboratory Medicine, The University of Southern California, Los Angeles, CA.
J Appl Lab Med ; 6(5): 1305-1315, 2021 09 01.
Article em En | MEDLINE | ID: mdl-33930144
ABSTRACT

BACKGROUND:

COVID-19, the disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can present with symptoms ranging from none to severe. Thrombotic events occur in a significant number of patients with COVID-19, especially in critically ill patients. This apparent novel form of coagulopathy is termed COVID-19-associated coagulopathy (CAC), and endothelial derived von Willebrand factor (vWF) may play an important role in its pathogenesis. CONTENT vWF is a multimeric glycoprotein molecule that is involved in inflammation, primary and secondary hemostasis. Studies have shown that patients with COVID-19 have significantly elevated levels of vWF antigen and activity, likely contributing to an increased risk of thrombosis seen in CAC. The high levels of both vWF antigen and activity have been clinically correlated with worse outcomes. Furthermore, the severity of a COVID-19 infection appears to reduce molecules that regulate vWF level and activity such as ADAMTS-13 and high-density lipoproteins (HDL). Finally, studies have suggested that patients with group O blood (a blood group with lower baseline levels of vWF) have a lower risk of infection and disease severity compared to other ABO blood groups; however, more studies are needed to elucidate the role of vWF.

SUMMARY:

CAC is a significant contributor to morbidity and mortality. Endothelial dysfunction with the release of prothrombotic factors, such as vWF, needs further examination as a possible important component in the pathogenesis of CAC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Fator de von Willebrand / COVID-19 Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Appl Lab Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Fator de von Willebrand / COVID-19 Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Appl Lab Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá