Direct <i>N</i>-alkylation of sulfur-containing amines.

Li, Chen; Ge, Min-Tong; Bai, Liang; Xia, Ai-Bao; Xu, Dan-Qian; Xu, Zhen-Yuan

Direct N-alkylation of sulfur-containing amines.

Li, Chen; Ge, Min-Tong; Bai, Liang; Xia, Ai-Bao; Xu, Dan-Qian; Xu, Zhen-Yuan.

Afiliação

Li C; Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China. xiaaibao@zjut.edu.cn chrc@zjut.edu.cn.
Ge MT; Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China. xiaaibao@zjut.edu.cn chrc@zjut.edu.cn.
Bai L; Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China. xiaaibao@zjut.edu.cn chrc@zjut.edu.cn.
Xia AB; Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China. xiaaibao@zjut.edu.cn chrc@zjut.edu.cn.
Xu DQ; Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China. xiaaibao@zjut.edu.cn chrc@zjut.edu.cn.
Xu ZY; Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China. xiaaibao@zjut.edu.cn chrc@zjut.edu.cn.

Org Biomol Chem ; 19(20): 4478-4482, 2021 05 26.

Article em En | MEDLINE | ID: mdl-33950054

ABSTRACT

ABSTRACT

An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy. The present methodology features base-free conditions and broad substrate scope, with water being the only by-product. Moreover, this protocol has been applied to the synthesis of the pharmaceutical drug Quetiapine.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article

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