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Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer.
Duan, Ying-Chao; Jin, Lin-Feng; Ren, Hong-Mei; Zhang, Shao-Jie; Liu, Yue-Jiao; Xu, Yong-Tao; He, Zi-Hao; Song, Yu; Yuan, Hang; Chen, Shu-Hui; Guan, Yuan-Yuan.
Afiliação
  • Duan YC; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China. Electronic address: duanyingchao1986@163.com.
  • Jin LF; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
  • Ren HM; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Z
  • Zhang SJ; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
  • Liu YJ; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Z
  • Xu YT; School of Medical Engineering, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
  • He ZH; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, ChaoYang District, Beijing, 100029, China.
  • Song Y; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
  • Yuan H; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
  • Chen SH; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
  • Guan YY; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China. Electronic address: 131011@xxmu.edu.cn.
Eur J Med Chem ; 220: 113453, 2021 Aug 05.
Article em En | MEDLINE | ID: mdl-33957387
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Desenho de Fármacos / Inibidores Enzimáticos / Histona Desmetilases / Histona Desacetilases / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de publicação: França
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Desenho de Fármacos / Inibidores Enzimáticos / Histona Desmetilases / Histona Desacetilases / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de publicação: França