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Entry-competent-replication-abortive African horse sickness virus strains elicit robust immunity in ponies against all serotypes.
Sullivan, Edward; Lecollinet, Sylvie; Kerviel, Adeline; Hue, Erika; Pronost, Stéphane; Beck, Cécile; Dumarest, Marine; Zientara, Stephan; Roy, Polly.
Afiliação
  • Sullivan E; Department of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, United Kingdom.
  • Lecollinet S; Université Paris-Est ANSES Alfort, UMR 1161 Virologie ANSES, INRA, ENVA, Maisons-Alfort, France.
  • Kerviel A; Department of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, United Kingdom.
  • Hue E; LABÉO Frank Duncombe, 14280 Saint-Contest, France; BIOTARGEN, Normandie Univ, UNICAEN, 14000 Caen, France.
  • Pronost S; LABÉO Frank Duncombe, 14280 Saint-Contest, France; BIOTARGEN, Normandie Univ, UNICAEN, 14000 Caen, France.
  • Beck C; Université Paris-Est ANSES Alfort, UMR 1161 Virologie ANSES, INRA, ENVA, Maisons-Alfort, France.
  • Dumarest M; Université Paris-Est ANSES Alfort, UMR 1161 Virologie ANSES, INRA, ENVA, Maisons-Alfort, France.
  • Zientara S; Université Paris-Est ANSES Alfort, UMR 1161 Virologie ANSES, INRA, ENVA, Maisons-Alfort, France.
  • Roy P; Department of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, United Kingdom. Electronic address: polly.roy@lshtm.ac.uk.
Vaccine ; 39(23): 3161-3168, 2021 05 27.
Article em En | MEDLINE | ID: mdl-33958224
ABSTRACT
African horse sickness virus (AHSV) is an Orbivirus within the Reoviridae family, spread by Culicoides species of midges, which infects equids with high mortality, particularly in horses and has a considerable impact on the equine industry. In order to control the disease, we previously described Entry Competent Replication Abortive (ECRA) virus strains for each of the nine distinct AHSV serotypes and demonstrated their potential as vaccines, first in type I interferon receptor (IFNAR-/-) knockout mice, and then in ponies. In this report we have investigated whether or not a combination ECRA vaccine comprising nine vaccine strains as two different cocktails is as efficient in ponies and the duration of the immunity triggered by ECRA vaccines. In one study, a group of ponies were vaccinated with a cocktail of 4 vaccine strains, followed by a vaccination of the remaining 5 vaccine strains, mimicking the current live attenuated vaccine regimen. In the second study, ponies were vaccinated with a single ECRA-AHSV strain and monitored for 6 months. The first group of ponies developed neutralising antibody responses against all 9 serotypes, indicating that no cross-serotype interference occurred, while the second group developed robust neutralising antibody responses against the single serotype that were sustained at the same level throughout a 6-month study. The results support our previous data and further validate ECRA vaccines as a safe and efficacious replacement of current live vaccines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Virais / Doença Equina Africana / Vírus da Doença Equina Africana Limite: Animals Idioma: En Revista: Vaccine Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Virais / Doença Equina Africana / Vírus da Doença Equina Africana Limite: Animals Idioma: En Revista: Vaccine Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido