Stopping the Clock on Seizures!

Fu, Xiaoqin; Liu, Judy S; Li, Peijun

Fu, Xiaoqin; Liu, Judy S; Li, Peijun.

Afiliação

Fu X; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Liu JS; Department of Neurology, Brown University, Providence, RI 02903, USA; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA. Electronic address: judy_liu@brown.edu.
Li P; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. Electronic address: 218004@wzhealth.com.

Trends Neurosci ; 44(6): 422-423, 2021 06.

Article em En | MEDLINE | ID: mdl-33965214

ABSTRACT

ABSTRACT

A recent paper by Zhang et al. shows that REV-ERBα, a negative regulator of the circadian molecular clock, is pro-convulsant through its action on GABA signaling. The findings support the role of the circadian molecular clock in epilepsy and suggest REV-ERBα as a potential therapeutic target for the management of seizures.

Assuntos

Relógios Circadianos; Membro 1 do Grupo D da Subfamília 1 de Receptores Nucleares; Ritmo Circadiano; Humanos; Membro 1 do Grupo D da Subfamília 1 de Receptores Nucleares/metabolismo; Convulsões; Transdução de Sinais

Palavras-chave

circadian molecular clock; epilepsy; tonic GABA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membro 1 do Grupo D da Subfamília 1 de Receptores Nucleares / Relógios Circadianos Limite: Humans Idioma: En Revista: Trends Neurosci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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