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Zingiber roseum Rosc. rhizome: A rich source of hepatoprotective polyphenols.
Amanat, Muhammed; Reza, Md Sharif; Shuvo, Md Sadikur Rahman; Ahmed, Khondoker Shahin; Hossain, Hemayet; Tawhid, Muhammad; Saifuzzaman, Md; Islam, Mohammad Shariful; Mazumder, Tanoy; Islam, Md Amirul; Daula, A F M Shahid Ud.
Afiliação
  • Amanat M; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address: mdamanat31@gmail.com.
  • Reza MS; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address: shorifahmedniloy@gmail.com.
  • Shuvo MSR; Department of Microbiology, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address: rs.sadik@gmail.com.
  • Ahmed KS; Chemical Research Division, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh. Electronic address: shahinjnu005@gmail.com.
  • Hossain H; Chemical Research Division, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh. Electronic address: hemayet.hossain02@gmail.com.
  • Tawhid M; Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology, Bangladesh. Electronic address: mdtawhidbge@gmail.com.
  • Saifuzzaman M; Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladeshiversity, Sonapur, Noakhali 3814, Bangladesh. Electronic address: saifuzzaman17@yahoo.com.
  • Islam MS; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address: sharifme47@gmail.com.
  • Mazumder T; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address: tanoybpharm6@gmail.com.
  • Islam MA; Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladeshiversity, Sonapur, Noakhali 3814, Bangladesh. Electronic address: ma.islam@pharm.ku.ac.bd.
  • Daula AFMSU; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address: shahidnstu@gmail.com.
Biomed Pharmacother ; 139: 111673, 2021 Jul.
Article em En | MEDLINE | ID: mdl-33965729
ABSTRACT
Zingiber roseum is native to Bangladesh and widely used in folk medicine. This present study was designed to assess the ameliorative potential of Zingiber roseum rhizome extract in carbon tetrachloride (CCl4) induced hepatotoxicity in mice model. Seven phenolic compounds were identified and quantified by HPLC analysis in the plant extract, including quercetin, myricetin, catechin hydrate, trans-ferulic acid, trans-cinnamic acid, (-) epicatechin, and rosmarinic acid. Hepatotoxicity was induced by administrating a single intraperitoneal injection of CCl4 (10 mL/kg) on 7th day of treatment. The results revealed that plant extract at all doses (100, 200 and 400 mg/kg) significantly reduced (p < 0.05) the elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) concentrations, and these effects were comparable to that of standard drug silymarin. Histopathological examination also revealed the evidence of recovery from CCL4 induced cellular damage when pretreated with Z. roseum rhizome extract. The in-vivo hepatoprotective effects were further investigated by the in-silico study of the aforementioned compounds with liver-protective enzymes such as superoxide dismutase (SOD), peroxiredoxin, and catalase. The strong binding affinities (ranging from -7.3359 to -9.111 KCal/mol) between the phenolic compounds (except trans-cinnamic acid) and oxidative stress enzymes inhibit ROS production during metabolism. The compounds were also found non-toxic in computational prediction, and a series of biological activities like antioxidant, anticarcinogen, cardio-protectant, hepato-protectant have been detected.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Intoxicação por Tetracloreto de Carbono / Zingiberaceae / Rizoma / Doença Hepática Induzida por Substâncias e Drogas / Polifenóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Intoxicação por Tetracloreto de Carbono / Zingiberaceae / Rizoma / Doença Hepática Induzida por Substâncias e Drogas / Polifenóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2021 Tipo de documento: Article