Microfluidic platform for synthesis and optimization of chitosan-coated magnetic nanoparticles in cisplatin delivery.
Carbohydr Polym
; 265: 118027, 2021 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-33966822
ABSTRACT
In this study, magnetic core/chitosan shell Nanoparticles (NPs) containing cisplatin were synthesized via cisplatin complexation with tripolyphosphate as the chitosan crosslinker using two different procedures a conventional batch flow method and a microfluidic approach. An integrated microfluidic device composed of three stages was developed to provide precise and highly controllable mixing. The comparison of the results revealed that NPs synthesized in microchannels were monodisperse 104⯱â¯14.59â¯nm (nâ¯=â¯3) in size with optimal morphological characteristics, whereas polydisperse 423⯱â¯53.33â¯nm (nâ¯=â¯3) nanoparticles were obtained by the conventional method. Furthermore, cisplatin was loaded in NPs without becoming inactivated, and the microfluidic technique demonstrated higher encapsulation efficiency, controlled release, and consequently lower IC50 values during exposure to the A2780 cell line proving that microfluidic synthesized NPs were able to enter the cells and release the drug more efficiently. The developed microfluidic platform presents valuable features that could potentially provide the clinical translation of NPs in drug delivery.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cisplatino
/
Sistemas de Liberação de Medicamentos
/
Microfluídica
/
Quitosana
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Nanopartículas de Magnetita
Limite:
Female
/
Humans
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Irã