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MTHFR C677T and A1298C variants in Mexican Mestizo infants with neural tube defects from Western Mexico.
Aranda-Sánchez, Cristian Irela; Bobadilla-Morales, Lucina; Corona-Rivera, Alfredo; Cuero-Quezada, Idalid; Santana-Hernández, Jennifer; Baldomero-López, Alejandra; Romero-Bolaño, Yaneris M; Peña-Padilla, Christian; Corona-Rivera, Jorge Román.
Afiliação
  • Aranda-Sánchez CI; Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division, "Dr. Juan I. Menchaca", Civil Hospital of Guadalajara, Guadalajara, Mexico.
  • Bobadilla-Morales L; Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division, "Dr. Juan I. Menchaca", Civil Hospital of Guadalajara, Guadalajara, Mexico.
  • Corona-Rivera A; "Dr. Enrique Corona-Rivera" Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico.
  • Cuero-Quezada I; Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division, "Dr. Juan I. Menchaca", Civil Hospital of Guadalajara, Guadalajara, Mexico.
  • Santana-Hernández J; "Dr. Enrique Corona-Rivera" Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico.
  • Baldomero-López A; "Dr. Enrique Corona-Rivera" Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico.
  • Romero-Bolaño YM; "Dr. Enrique Corona-Rivera" Institute of Human Genetics, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico.
  • Peña-Padilla C; Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division, "Dr. Juan I. Menchaca", Civil Hospital of Guadalajara, Guadalajara, Mexico.
  • Corona-Rivera JR; Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division, "Dr. Juan I. Menchaca", Civil Hospital of Guadalajara, Guadalajara, Mexico.
Congenit Anom (Kyoto) ; 61(5): 188-192, 2021 Sep.
Article em En | MEDLINE | ID: mdl-34015145
ABSTRACT
Our study investigated the role of MTHFR C677T and A1298C variants in infants with neural tube defects (NTDs) from western Mexico. Using TaqMan allelic discrimination assay, we genotyped 101 live-born patients with NTDs (cases) and 247 controls. Our findings do not support that homozygosity or heterozygosity for the variants C677T and A1298C in the MTHFR gene are associated with NTDs in infants. However, since we have the highest worldwide frequency of homozygotes for the MTHFR C677T variant, we cannot rule out that our propensity for NTDs may be related to how such gene variant interacts with other factors, mainly with our secular patterns of inappropriate folate intake.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metilenotetra-Hidrofolato Redutase (NADPH2) / Defeitos do Tubo Neural Limite: Humans / Infant País/Região como assunto: Mexico Idioma: En Revista: Congenit Anom (Kyoto) Assunto da revista: TERATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metilenotetra-Hidrofolato Redutase (NADPH2) / Defeitos do Tubo Neural Limite: Humans / Infant País/Região como assunto: Mexico Idioma: En Revista: Congenit Anom (Kyoto) Assunto da revista: TERATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México