Multi-photon absorption organotin complex for bioimaging and promoting ROS generation.
Spectrochim Acta A Mol Biomol Spectrosc
; 260: 119923, 2021 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-34015744
ABSTRACT
Compared to general fluorescent dyes, multi-photon fluorescent dyes exhibit deeper tissue penetration and lower auto-fluorescence in the bio-imaging field. Therefore, it is necessary to develop an efficient multiphoton imaging agent for deep tissue imaging. In this work, an organotin derivative (HSnBu3) has been designed and synthesized, which shows multiphoton absorption activity. In constrast to the ignorable three-photon activity of the ligand, the complex (HSnBu3) exhibits three-photon activity under NIR excitation (1500 nm). Results of chemical and biological tests confirmed that HSnBu3 was more easily activated by oxygen resulting in a higher level of 1O2, which could induce a decrease in mitochondrial membrane potential in HepG2 cells. It suggests that HSnBu3 has potential in photodynamic therapy.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Fótons
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Spectrochim Acta A Mol Biomol Spectrosc
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2021
Tipo de documento:
Article