Mechanistic insight into the capacity of natural polar phenolic compounds to abolish Alzheimer's disease-associated pathogenic effects of apoE4 forms.

Mountaki, Christina; Dafnis, Ioannis; Panagopoulou, Eirini A; Vasilakopoulou, Paraskevi B; Karvelas, Michalis; Chiou, Antonia; Karathanos, Vaios T; Chroni, Angeliki

Mountaki, Christina; Dafnis, Ioannis; Panagopoulou, Eirini A; Vasilakopoulou, Paraskevi B; Karvelas, Michalis; Chiou, Antonia; Karathanos, Vaios T; Chroni, Angeliki.

Afiliação

Mountaki C; Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos", Agia Paraskevi, Athens, Greece.
Dafnis I; Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos", Agia Paraskevi, Athens, Greece.
Panagopoulou EA; Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Dietetics and Nutrition, Harokopio University, Kallithea, Greece.
Vasilakopoulou PB; Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Dietetics and Nutrition, Harokopio University, Kallithea, Greece.
Karvelas M; Research and Development Department, Agricultural Cooperatives' Union of Aeghion, Aeghion, Greece.
Chiou A; Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Dietetics and Nutrition, Harokopio University, Kallithea, Greece.
Karathanos VT; Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Dietetics and Nutrition, Harokopio University, Kallithea, Greece; Research and Development Department, Agricultural Cooperatives' Union of Aeghion, Aeghion, Greece.
Chroni A; Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos", Agia Paraskevi, Athens, Greece. Electronic address: achroni@bio.demokritos.gr.

Free Radic Biol Med ; 171: 284-301, 2021 08 01.

Article em En | MEDLINE | ID: mdl-34019932

Assuntos

Doença de Alzheimer; Apolipoproteína E4; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/genética; Peptídeos beta-Amiloides; Apolipoproteína E4/genética; Humanos; Neurônios; Fenóis/farmacologia

Palavras-chave

Alzheimer disease; Amyloidbeta (Aß); Antioxidant; Apolipoprotein E (ApoE); Natural product; Neuroprotection; Oxidative stress; Plasma membrane; Protein conformation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteína E4 / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Grécia

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