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Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity.
Mohamed, Fatma A M; Gomaa, Hesham A M; Hendawy, O M; Ali, Asmaa T; Farghaly, Hatem S; Gouda, Ahmed M; Abdelazeem, Ahmed H; Abdelrahman, Mostafa H; Trembleau, Laurent; Youssif, Bahaa G M.
Afiliação
  • Mohamed FAM; Clinical Laboratory Science Department, College of Applied Medical Sciences, Jouf University, Aljouf 72341, Saudi Arabia; Chemistry Department, Faculty of Science, Alexandria University, Alexandria-21321, Egypt.
  • Gomaa HAM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia.
  • Hendawy OM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia; Department of Clinical Pharmacology, Faculty of Medicine, Beni-Suef University, Egypt.
  • Ali AT; Biochemistry Department, Faculty of Pharmacy, Nahda University, Beni-Suef 62511, Egypt.
  • Farghaly HS; Biochemistry Department, Faculty of Pharmacy, Nahda University, Beni-Suef 62511, Egypt.
  • Gouda AM; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Abdelazeem AH; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
  • Abdelrahman MH; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
  • Trembleau L; School of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB243UE, United Kingdom.
  • Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: bahaa.youssif@pharm.aun.edu.eg.
Bioorg Chem ; 112: 104960, 2021 07.
Article em En | MEDLINE | ID: mdl-34020242
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Apoptose / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Egito País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Apoptose / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Egito País de publicação: Estados Unidos