The crystal structure of mouse SULT2A8 reveals the mechanism of 7&#945;-hydroxyl, bile acid sulfation.

Teramoto, Takamasa; Nishio, Takeaki; Kurogi, Katsuhisa; Sakakibara, Yoichi; Kakuta, Yoshimitsu

The crystal structure of mouse SULT2A8 reveals the mechanism of 7α-hydroxyl, bile acid sulfation.

Teramoto, Takamasa; Nishio, Takeaki; Kurogi, Katsuhisa; Sakakibara, Yoichi; Kakuta, Yoshimitsu.

Afiliação

Teramoto T; Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 819-0395, Japan.
Nishio T; Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 819-0395, Japan.
Kurogi K; Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, 889-2192, Japan.
Sakakibara Y; Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, 889-2192, Japan.
Kakuta Y; Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 819-0395, Japan. Electronic address: kakuta@agr.kyushu-u.ac.jp.

Biochem Biophys Res Commun ; 562: 15-20, 2021 07 12.

Article em En | MEDLINE | ID: mdl-34030040

Assuntos

Ácidos e Sais Biliares/metabolismo; Sulfatos/metabolismo; Sulfotransferases/química; Sequência de Aminoácidos; Animais; Sítios de Ligação; Biocatálise; Cristalografia por Raios X; Humanos; Cinética; Camundongos; Modelos Moleculares; Proteínas Mutantes/química; Proteínas Mutantes/metabolismo; Especificidade por Substrato; Sulfotransferases/metabolismo

Palavras-chave

Bile acid and salts/metabolism; Bile acid metabolism; Cytosolic sulfotransferase; Enzymology; Liver; Species differences; Sulfation; X-ray crystallography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfatos / Ácidos e Sais Biliares / Sulfotransferases Tipo de estudo: Guideline Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos

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