Synergistic interactions of anti-NS1 monoclonal antibodies protect passively immunized mice from lethal challenge with dengue 2 virus.
J Gen Virol
; 69 ( Pt 8): 2101-7, 1988 Aug.
Article
em En
| MEDLINE
| ID: mdl-3404125
ABSTRACT
Non-neutralizing, serotype-specific anti-NS1 monoclonal antibodies partially protected passively immunized mice from lethal dengue 2 virus intracerebral challenge. There was no apparent correlation between complement-fixing activity and protective capacity among individual anti-NS1 monoclonal antibodies. Immunization with specific combinations of non-protective or partially protective antibodies resulted in prolonged survival or reduced mortality. Solid protection, equal to that achieved after immunization with neutralizing polyclonal antibody, was achieved only with an antibody pair which individually fixed complement to high titre with homologous virus. Some groups of mice had increased morbidity after immunization with combinations of protective monoclonal antibodies that bind to overlapping epitopes. These results may affect the design of recombinant dengue vaccines which may require the inclusion of serotype-specific antigenic domains.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunização Passiva
/
Dengue
/
Vírus da Dengue
/
Anticorpos Monoclonais
/
Antígenos Virais
Limite:
Animals
Idioma:
En
Revista:
J Gen Virol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Tailândia