Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry.
Prog Mol Subcell Biol
; 59: 51-97, 2021.
Article
em En
| MEDLINE
| ID: mdl-34050862
ABSTRACT
The endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca2+ channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and accessory proteins. Here, we review the recent progress in the identification and characterization of ER and cytosolic proteins interacting with STIM1 to control its activation and deactivation during store-operated Ca2+ entry (SOCE).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinalização do Cálcio
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Prog Mol Subcell Biol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Suíça