TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery.

Xiang, Shuang; Song, Shukai; Tang, Haotian; Smaill, Jeff B; Wang, Aiqun; Xie, Hua; Lu, Xiaoyun

Xiang, Shuang; Song, Shukai; Tang, Haotian; Smaill, Jeff B; Wang, Aiqun; Xie, Hua; Lu, Xiaoyun.

Afiliação

Xiang S; Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Song S; Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Tang H; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Smaill JB; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Wang A; Department of Anesthesiology, Guangzhou Red Cross Hospital Affiliated to Jinan University, Guangzhou 510220, China. Electronic address: wangaiqunhhyy@163.com.
Xie H; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: hxie@simm.ac.cn.
Lu X; Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: luxy2016@jnu.edu.cn.

Drug Discov Today ; 26(10): 2445-2455, 2021 10.

Article em En | MEDLINE | ID: mdl-34051368

RESUMO

Dysregulation of TANK-binding kinase 1 (TBK1) homeostasis leads to the occurrence and progression of many diseases, such as inflammation, autoimmune diseases, metabolic diseases, and cancer. Therefore, there is a need to develop TBK1 inhibitors as therapeutic agents. In this review, we highlight the diverse biological functions of TBK1 and summarize the promising small-molecule inhibitors of TBK1 that have the potential to be developed as therapeutic candidates.

Assuntos

Descoberta de Drogas/métodos; Inibidores de Proteínas Quinases/farmacologia; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Animais; Progressão da Doença; Desenvolvimento de Medicamentos/métodos; Humanos; Terapia de Alvo Molecular; Proteínas Serina-Treonina Quinases/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Descoberta de Drogas Limite: Animals / Humans Idioma: En Revista: Drug Discov Today Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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