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Frontal Fibrosing Alopecia: Is There a Link in Relatives?
Ocampo-Garza, Sonia Sofía; Orizaga-Y-Quiroga, Thelma Laura; Olvera-Rodríguez, Valeria; Herz-Ruelas, Maira Elizabeth; Chavez-Alvarez, Sonia; Vañó-Galván, Sergio; Ocampo-Candiani, Jorge.
Afiliação
  • Ocampo-Garza SS; Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Dermatology Department, Monterrey, Mexico.
  • Orizaga-Y-Quiroga TL; Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Dermatology Department, Monterrey, Mexico.
  • Olvera-Rodríguez V; Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Monterrey, Mexico.
  • Herz-Ruelas ME; Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Dermatology Department, Monterrey, Mexico.
  • Chavez-Alvarez S; Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Dermatology Department, Monterrey, Mexico.
  • Vañó-Galván S; Dermatology Department, Universidad de Alcalá, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
  • Ocampo-Candiani J; Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Dermatology Department, Monterrey, Mexico.
Skin Appendage Disord ; 7(3): 206-211, 2021 Apr.
Article em En | MEDLINE | ID: mdl-34055909
Frontal fibrosing alopecia (FFA) is an acquired primary lymphocytic cicatricial alopecia characterized by frontotemporal hairline recession, leading to scarring alopecia with a band-like distribution. Prevalence is increasing worldwide, being the most frequent cause of primary scarring alopecia. The natural history of this condition is variable; however, slow progression with spontaneous remission is the most frequent reported outcome. The etiopathogenesis of FFA remains to be elucidated; numerous hypotheses concerning hormonal effects, environmental factors, and genetic predisposition have been proposed. Special interest on genetic basis has emerged since the first familial case was reported. Only a few more familial cases have been published. We report 6 additional cases of female patients with familial FFA (F-FFA) from 3 different families. Sixty-six percent had a family history of autoimmune disease in first-degree relatives; these same patients had a personal history of autoimmune disease. The families described in this cohort study plus the personal and family history of autoimmune disease, as well as the recently described involved genomic loci; reinforced the hypothesis of this disease being genetic. It is important to consider studying this entity since there are scarce data regarding familial cases and this might give us a better insight toward understanding its pathogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Skin Appendage Disord Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Skin Appendage Disord Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Suíça