Identification of Pyruvate Dehydrogenase E1 as a Potential Target against <i>Magnaporthe oryzae</i> through Experimental and Theoretical Investigation.

Li, Yuejuan; Hu, Baichun; Wang, Zhibin; He, Jianhua; Zhang, Yaoliang; Wang, Jian; Guan, Lijie

Identification of Pyruvate Dehydrogenase E1 as a Potential Target against Magnaporthe oryzae through Experimental and Theoretical Investigation.

Li, Yuejuan; Hu, Baichun; Wang, Zhibin; He, Jianhua; Zhang, Yaoliang; Wang, Jian; Guan, Lijie.

Afiliação

Li Y; Department of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Hu B; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110142, China.
Wang Z; Key Laboratory of Intelligent Drug Design and New Drug Discovery of Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110142, China.
He J; Department of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Zhang Y; Department of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China.
Wang J; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110142, China.
Guan L; Key Laboratory of Intelligent Drug Design and New Drug Discovery of Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110142, China.

Int J Mol Sci ; 22(10)2021 May 13.

Article em En | MEDLINE | ID: mdl-34068366

Assuntos

Chalconas/farmacologia; Proteínas Fúngicas/metabolismo; Magnaporthe/efeitos dos fármacos; Oryza/enzimologia; Doenças das Plantas/imunologia; Piruvato Desidrogenase (Lipoamida)/antagonistas & inibidores; Transcriptoma/efeitos dos fármacos; Proteínas Fúngicas/genética; Fungicidas Industriais/farmacologia; Perfilação da Expressão Gênica; Regulação Fúngica da Expressão Gênica; Magnaporthe/fisiologia; Simulação de Acoplamento Molecular; Oryza/efeitos dos fármacos; Oryza/microbiologia; Doenças das Plantas/microbiologia; Conformação Proteica; Piruvato Desidrogenase (Lipoamida)/genética; Piruvato Desidrogenase (Lipoamida)/metabolismo

Palavras-chave

RNA sequencing; enzyme activity; homology modeling; isobavachalcone; molecular dynamics simulation; pyruvate dehydrogenase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Plantas / Oryza / Proteínas Fúngicas / Magnaporthe / Piruvato Desidrogenase (Lipoamida) / Chalconas / Transcriptoma Tipo de estudo: Diagnostic_studies / Guideline Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Suíça

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