Comparison of Povidone-Iodine and Gentamicin Soak as Scleral Buckle Infection Prophylaxis.
Clin Ophthalmol
; 15: 2203-2209, 2021.
Article
em En
| MEDLINE
| ID: mdl-34079217
ABSTRACT
OBJECTIVE:
To determine the best method of antimicrobial prophylaxis against implanted material-associated infections in the setting of scleral buckle surgery.DESIGN:
Experimental study.PARTICIPANTS:
Scleral buckle elements were soaked in either gram-positive or polymicrobial broth, while control buckle elements were soaked in PBS only.METHODS:
Solid silicone and sponge scleral buckle elements were inoculated with common pathogens of the ocular surface, and then soaked in either 1% or 5% povidone-iodine, 1 mg/mL gentamicin solution, or sterile saline for 1, 5, 10, or 15 minutes. Bacteria were then isolated from the buckle elements and cultured for 24 hours.RESULTS:
In all gram-positive bacterial conditions, gentamicin solution decreased the bacterial load from 451,666.67 colony-forming units (CFU)/mL to 171,611.11 CFU/mL (p=0.0004). The fractional bacterial survival after soaking in gentamicin was higher for the silicone sponge than band (0.357 vs 0.079, p=0.038). Both 1% and 5% povidone-iodine were able to completely eradicate all gram-positive bacteria of both buckle elements. Only 5% povidone-iodine was able to completely sterilize all microbes on the buckle after soaking in a polymicrobial solution consisting of gram-positive, gram-negative bacteria, and fungi.CONCLUSION:
Povidone-iodine solution was significantly more effective at bacterial eradication compared to gentamicin solution. For all scleral buckle procedures, we recommend soaking the buckle element in 2-3% povidone-iodine solution before placement and rinsing the ocular surface with the same solution after placement.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Clin Ophthalmol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos