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The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models.
Stegmann, Kim M; Dickmanns, Antje; Gerber, Sabrina; Nikolova, Vella; Klemke, Luisa; Manzini, Valentina; Schlösser, Denise; Bierwirth, Cathrin; Freund, Julia; Sitte, Maren; Lugert, Raimond; Salinas, Gabriela; Meister, Toni Luise; Pfaender, Stephanie; Görlich, Dirk; Wollnik, Bernd; Groß, Uwe; Dobbelstein, Matthias.
Afiliação
  • Stegmann KM; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Dickmanns A; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Gerber S; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Nikolova V; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Klemke L; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Manzini V; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Schlösser D; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Bierwirth C; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Freund J; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Sitte M; NGS Integrative Genomics Core Unit, Institute of Human Genetics, University Medical Center Göttingen, Germany.
  • Lugert R; Institute of Medical Microbiology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Salinas G; NGS Integrative Genomics Core Unit, Institute of Human Genetics, University Medical Center Göttingen, Germany.
  • Meister TL; Department of Molecular and Medical Virology, Ruhr University Bochum, Germany.
  • Pfaender S; Department of Molecular and Medical Virology, Ruhr University Bochum, Germany.
  • Görlich D; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
  • Wollnik B; Institute of Human Genetics, University Medical Center Göttingen, Germany.
  • Groß U; Institute of Medical Microbiology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany.
  • Dobbelstein M; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Germany. Electronic address: mdobbel@uni-goettingen.de.
Virus Res ; 302: 198469, 2021 09.
Article em En | MEDLINE | ID: mdl-34090962
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Monofosfato de Adenosina / Metotrexato / Alanina / Antagonistas do Ácido Fólico / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Revista: Virus Res Assunto da revista: VIROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Monofosfato de Adenosina / Metotrexato / Alanina / Antagonistas do Ácido Fólico / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Limite: Animals / Humans Idioma: En Revista: Virus Res Assunto da revista: VIROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Holanda