BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia.
Blood Adv
; 5(11): 2550-2562, 2021 06 08.
Article
em En
| MEDLINE
| ID: mdl-34100903
ABSTRACT
Neutrophils help to clear pathogens and cellular debris, but can also cause collateral damage within inflamed tissues. Prolonged neutrophil residency within an inflammatory niche can exacerbate tissue pathology. Using both genetic and pharmacological approaches, we show that BCL-XL is required for the persistence of neutrophils within inflammatory sites in mice. We demonstrate that a selective BCL-XL inhibitor (A-1331852) has therapeutic potential by causing apoptosis in inflammatory human neutrophils ex vivo. Moreover, in murine models of acute and chronic inflammatory disease, it reduced inflammatory neutrophil numbers and ameliorated tissue pathology. In contrast, there was minimal effect on circulating neutrophils. Thus, we show a differential survival requirement in activated neutrophils for BCL-XL and reveal a new therapeutic approach to neutrophil-mediated diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neutropenia
/
Neutrófilos
Limite:
Animals
Idioma:
En
Revista:
Blood Adv
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália