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CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia.
Lodder, Chritica; Scheyltjens, Isabelle; Stancu, Ilie Cosmin; Botella Lucena, Pablo; Gutiérrez de Ravé, Manuel; Vanherle, Sarah; Vanmierlo, Tim; Cremers, Niels; Vanrusselt, Hannah; Brône, Bert; Hanseeuw, Bernard; Octave, Jean-Noël; Bottelbergs, Astrid; Movahedi, Kiavash; Dewachter, Ilse.
Afiliação
  • Lodder C; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Scheyltjens I; Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.
  • Stancu IC; Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
  • Botella Lucena P; Laboratory for Molecular and Cellular Therapy, Department of Biomedical Sciences, Vrije Universiteit Brussel, Beerse, Belgium.
  • Gutiérrez de Ravé M; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Vanherle S; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Vanmierlo T; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Cremers N; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Vanrusselt H; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Brône B; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Hanseeuw B; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Octave JN; Department of Neurosciences, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Bottelbergs A; Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
  • Movahedi K; Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Dewachter I; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Acta Neuropathol Commun ; 9(1): 108, 2021 06 08.
Article em En | MEDLINE | ID: mdl-34103079
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Microglia / Modelos Animais de Doenças / Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Bélgica País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Microglia / Modelos Animais de Doenças / Doença de Alzheimer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Commun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Bélgica País de publicação: Reino Unido