Challenges for design of aggregation-resistant variants of granulocyte colony-stimulating factor.

Meric, Gulsum; Naik, Subhashchandra; Hunter, Alan K; Robinson, Anne S; Roberts, Christopher J

Meric, Gulsum; Naik, Subhashchandra; Hunter, Alan K; Robinson, Anne S; Roberts, Christopher J.

Afiliação

Meric G; Chemical & Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States. Electronic address: gmeric@udel.edu.
Naik S; Chemical & Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States. Electronic address: snaik@reformbiologics.com.
Hunter AK; Biopharmaceuticals Development, R&D, AstraZeneca, Gaithersburg, MD 20878, United States. Electronic address: alan.hunter@astrazeneca.com.
Robinson AS; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, United States. Electronic address: asrobins@andrew.cmu.edu.
Roberts CJ; Chemical & Biomolecular Engineering, University of Delaware, Newark, DE 19716, United States. Electronic address: cjr@udel.edu.

Biophys Chem ; 277: 106630, 2021 10.

Article em En | MEDLINE | ID: mdl-34119805

Assuntos

Proteínas Recombinantes; Fator Estimulador de Colônias de Granulócitos; Cinética; Agregados Proteicos; Dobramento de Proteína; Temperatura

Palavras-chave

Aggregation hot spots/aggregation-prone-regions (APRs); Conformational stability; Intrinsic aggregation propensity (IAP); Non-native protein aggregation; Protein engineering; Rational design

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes Tipo de estudo: Prognostic_studies Idioma: En Revista: Biophys Chem Ano de publicação: 2021 Tipo de documento: Article País de publicação: Holanda

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