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The Postnatal Leptin Surge Supports Immune Cell Function in Rats.
Hunsche, Caroline; Hernandez, Oskarina; Mela, Virginia; Viveros, M Paz; De la Fuente, Mónica.
Afiliação
  • Hunsche C; Department of Genetics, Physiology and Microbiology (Unit of Animal Physiology). Faculty of Biology, Complutense University of Madrid, Madrid, Spain.
  • Hernandez O; Research Institute of Hospital 12 de Octubre (I+12), Madrid, Spain.
  • Mela V; Department of Genetics, Physiology and Microbiology (Unit of Animal Physiology). Faculty of Biology, Complutense University of Madrid, Madrid, Spain.
  • Viveros MP; Department of Genetics, Physiology and Microbiology (Unit of Animal Physiology). Faculty of Biology, Complutense University of Madrid, Madrid, Spain.
  • De la Fuente M; Department of Genetics, Physiology and Microbiology (Unit of Animal Physiology). Faculty of Biology, Complutense University of Madrid, Madrid, Spain.
Immunol Invest ; 51(5): 1347-1363, 2022 Jul.
Article em En | MEDLINE | ID: mdl-34121590
ABSTRACT

BACKGROUND:

Leptin plays an important role in the regulation of the immune response. There is a physiological surge of leptin in rodents during the neonatal period, which has mainly been studied in the context of brain development. However, little is known about the effects of this neonatal leptin surge on immunity. Therefore, we investigated whether blocking this leptin surge could affect several immune functions.

METHODS:

Male and female rats were injected subcutaneously with 5 mg/Kg/day of rat pegylated super leptin antagonist during the neonatal period (PND5-9). On the peripubertal period, relevant functions as well as cytokine release by spleen leukocytes were studied in these animals.

RESULTS:

The results showed that the animals significantly display an impaired anti-tumor NK activity and chemotactic and proliferation capacity of lymphocytes in response to mitogens. In addition, several cytokine concentrations, released under mitogen-stimulated conditions, were also altered.

CONCLUSION:

In conclusion, the neonatal leptin surge seems to be involved in the establishment of an adequate immune response and cytokine profile, which are crucial for the maintenance of a healthy life.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leptina / Crescimento e Desenvolvimento Limite: Animals Idioma: En Revista: Immunol Invest Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leptina / Crescimento e Desenvolvimento Limite: Animals Idioma: En Revista: Immunol Invest Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha