Human amyloid beta and &#945;-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans.

Huang, Xiaobing; Wang, Changliang; Chen, Liang; Zhang, Tianjiao; Leung, Ka Lai; Wong, Garry

Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans.

Huang, Xiaobing; Wang, Changliang; Chen, Liang; Zhang, Tianjiao; Leung, Ka Lai; Wong, Garry.

Afiliação

Huang X; Cancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau 999078, China.
Wang C; Cancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau 999078, China; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China.
Chen L; Department of Computer Science, College of Engineering, Shantou University, Shantou 515063, China; Key Laboratory of Intelligent Manufacturing Technology of Ministry of Education, Shantou University, Shantou 515063, China.
Zhang T; Cancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau 999078, China.
Leung KL; Cancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau 999078, China.
Wong G; Cancer Centre, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau 999078, China. Electronic address: garrygwong@umac.mo.

Biochim Biophys Acta Mol Basis Dis ; 1867(10): 166203, 2021 10 01.

Article em En | MEDLINE | ID: mdl-34146705

Assuntos

Peptídeos beta-Amiloides/metabolismo; Caenorhabditis elegans/metabolismo; Doença por Corpos de Lewy/metabolismo; Neurônios/metabolismo; alfa-Sinucleína/metabolismo; Idoso; Doença de Alzheimer/metabolismo; Animais; Animais Geneticamente Modificados/metabolismo; Encéfalo/metabolismo; Humanos; Metabolismo dos Lipídeos/fisiologia; Lisossomos/metabolismo; Pessoa de Meia-Idade; Doença de Parkinson/metabolismo; Transcriptoma/fisiologia

Palavras-chave

Amyloid ß; Lewy body dementia; Lipid metabolism; Lysosome function; α-Synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Caenorhabditis elegans / Doença por Corpos de Lewy / Alfa-Sinucleína / Neurônios Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Humans / Middle aged Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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