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Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype.
Li, Hao; Wu, Shihao; Ma, Xia; Li, Xiao; Cheng, Tianlin; Chen, Zhifang; Wu, Jing; Lv, Longbao; Li, Ling; Xu, Liqi; Wang, Wenchao; Hu, Yingzhou; Jiang, Haisong; Yin, Yong; Qiu, Zilong; Hu, Xintian.
Afiliação
  • Li H; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China.
  • Wu S; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China.
  • Ma X; Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Li X; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China.
  • Cheng T; Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
  • Chen Z; Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Wu J; Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Lv L; Institute of Neuroscience, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Li L; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China.
  • Xu L; National Resource Center for Non-human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, 650107, Kunming, China.
  • Wang W; Diagnostic Radiology Department, 920 Hospital of the Joint Logistics Support Force of the PLA, Kunming, 650032, China.
  • Hu Y; Ultrasound diagnosis Department, 920 Hospital of the Joint Logistics Support Force of the PLA, Kunming, 650032, China.
  • Jiang H; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China.
  • Yin Y; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China.
  • Qiu Z; Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
  • Hu X; Department of Rehabilitation Medicine, The Second People's Hospital of Yunnan Province, Kunming, 650021, China. yinyong@ynshhyy.com.
Neurosci Bull ; 37(9): 1271-1288, 2021 Sep.
Article em En | MEDLINE | ID: mdl-34165772
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dependovirus / Sistemas CRISPR-Cas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Neurosci Bull Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Singapura
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dependovirus / Sistemas CRISPR-Cas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Neurosci Bull Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Singapura