Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota.
J Invest Dermatol
; 141(7): 1630-1632, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-34167722
ABSTRACT
Shi et al. (2021) in "Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice" show that Western diet (WD) exacerbates an IL-23 minicircleâmediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17Aâexpressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulation may be useful in the treatment of IL-23âmediated disease, possibly through the modulation of the gut microbiota.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psoríase
/
Microbioma Gastrointestinal
/
Artropatias
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Invest Dermatol
Ano de publicação:
2021
Tipo de documento:
Article