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Tailoring the Architecture of Cationic Polymer Brush-Modified Carbon Nanotubes for Efficient siRNA Delivery in Cancer Immunotherapy.
Li, Danyang; Ahmed, Momina; Khan, Anisah; Xu, Lizhou; Walters, Adam A; Ballesteros, Belén; Al-Jamal, Khuloud T.
Afiliação
  • Li D; Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH U.K.
  • Ahmed M; Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH U.K.
  • Khan A; Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH U.K.
  • Xu L; Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH U.K.
  • Walters AA; Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH U.K.
  • Ballesteros B; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, Barcelona 08193, Spain.
  • Al-Jamal KT; Institute of Pharmaceutical Science, Faculty of Life Science & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH U.K.
ACS Appl Mater Interfaces ; 13(26): 30284-30294, 2021 Jul 07.
Article em En | MEDLINE | ID: mdl-34170101
The facile and controlled fabrication of homogeneously grafted cationic polymers on carbon nanotubes (CNTs) remains poorly investigated, which further hinders the understanding of interactions between functionalized CNTs with different nucleic acids and the rational design of appropriate gene delivery vehicles. Herein, we describe the controlled grafting of cationic poly(2-dimethylaminoethylmethacrylate) brushes on CNTs via surface-initiated atom transfer radical polymerization integrated with mussel-inspired polydopamine chemistry. The binding of nucleic acids with different brush-CNT hybrids discloses the highly architectural-dependent behavior with dense short brush-coated CNTs displaying the highest binding among all the other hybrids, namely, dense long, sparse long, and sparse short brush-coated CNTs. Additionally, different chemistries of the brush coatings were shown to influence the biocompatibility, cellular uptake, and silencing efficiency in vitro. This platform provides great flexibility for the design of polymer brush-CNT hybrids with precise control over their structure-activity relationship for the rational design of nucleic acid delivery systems.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Nanotubos de Carbono / RNA Interferente Pequeno / Metacrilatos / Antineoplásicos / Nylons Limite: Animals Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Nanotubos de Carbono / RNA Interferente Pequeno / Metacrilatos / Antineoplásicos / Nylons Limite: Animals Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos