The effect of anticoagulants in blood collection tubes on Plasmodium falciparum transmission in direct membrane feeding assays.
Trans R Soc Trop Med Hyg
; 116(2): 187-189, 2022 02 01.
Article
em En
| MEDLINE
| ID: mdl-34182573
ABSTRACT
BACKGROUND:
Direct membrane feeding assays assess the transmission potential of malaria-infected individuals using whole blood collected in anticoagulant vacutainers.METHODS:
The potential inhibitory effect of four commonly used anticoagulants on gametocyte infectivity to mosquitoes was assessed in standard membrane feeding assays with cultured Plasmodium falciparum.RESULTS:
Infection burden in mosquitoes was significantly reduced when blood was collected in sodium citrate and EDTA. Transmission was highest when blood was collected in lithium heparin and sodium heparin, although a concentration-dependent inhibition of mosquito infection was also observed.CONCLUSIONS:
Although anticoagulants can reduce transmission efficiency, lithium heparin and sodium heparin are the best anticoagulants for evaluating malaria transmission.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Malária Falciparum
/
Malária
/
Anopheles
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Holanda