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IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis.
Turnbull, Isaiah R; Mazer, Monty B; Hoofnagle, Mark H; Kirby, John P; Leonard, Jennifer M; Mejia-Chew, Carlos; Spec, Andrej; Blood, Jane; Miles, Sydney M; Ransom, Eric M; Potter, Robert F; Gaut, Joseph P; Remy, Kenneth E; Hotchkiss, Richard S.
Afiliação
  • Turnbull IR; Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Mazer MB; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Hoofnagle MH; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Kirby JP; Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Leonard JM; Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Mejia-Chew C; Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Spec A; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Blood J; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Miles SM; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Ransom EM; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Potter RF; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Gaut JP; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Remy KE; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Hotchkiss RS; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Open Forum Infect Dis ; 8(6): ofab256, 2021 Jun.
Article em En | MEDLINE | ID: mdl-34189174
ABSTRACT
A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos