Individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on lung cancer risk: A meta-analysis and re-analysis of systematic meta-analyses.
Medicine (Baltimore)
; 100(26): e26104, 2021 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-34190143
ABSTRACT
ABSTRACT Thirty-five previous meta-analyses have been reported on the individual glutathione S-transferase M1 (GSTM1) present/null, glutathione S-transferase T1 (GSTT1) present/null, and glutathione S-transferase P1 (GSTP1) IIe105Val polymorphisms with lung cancer (LC) risk. However, they did not appraise the credibility and explore the combined effects between the 3 genes and LC risk.We performed a meta-analysis and re-analysis of systematic previous meta-analyses to solve the above problems.Meta-analyses of Observational Studies in Epidemiology guidelines were used. Moreover, we employed false-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and the Venice criteria to verify the credibility of current and previous meta-analyses.Significantly increased LC risk was considered as "highly credible" or "positive" for GSTM1 null genotype in Japanese (odds ratio (OR)â=â1.30, 95% confidence interval (CI)â=â1.17-1.44, I2â=â0.0%, statistical powerâ=â0.997, FPRPâ=â0.008, BFDPâ=â0.037, and Venice criteria AAB), for GSTT1 null genotype in Asians (ORâ=â1.23, 95% CIâ=â1.12-1.36, I2â=â49.1%, statistical powerâ=â1.000, FPRPâ=â0.051, BFDPâ=â0.771, and Venice criteria ABB), especially Chinese populations (ORâ=â1.31, 95% CIâ=â1.16-1.49, I2â=â48.9%, Statistical powerâ=â0.980, FPRPâ=â0.039, BFDPâ=â0.673, and Venice criteria ABB), and for GSTP1 IIe105Val polymorphism in Asians (Val vs IIe ORâ=â1.28, 95% CIâ=â1.17-1.42, I2â=â30.3%, statistical powerâ=â0.999, FPRPâ=â0.003, BFDPâ=â0.183, and Venice criteria ABB). Significantly increased lung adenocarcinoma (AC) risk was also considered as "highly credible" or "positive" in Asians for the GSTM1 (ORâ=â1.35, 95% CIâ=â1.22-1.48, I2â=â25.5%, statistical powerâ=â0.988, FPRPâ<â0.001, BFDPâ<â0.001, and Venice criteria ABB) and GSTT1 (ORâ=â1.36, 95% CIâ=â1.17-1.58, I2â=â30.2%, statistical powerâ=â0.900, FPRPâ=â0.061, BFDPâ=â0.727, and Venice criteria ABB) null genotype.This study indicates that GSTM1 null genotype is associated with increased LC risk in Japanese and lung AC risk in Asians; GSTT1 null genotype is associated with increased LC risk in Chinese, and GSTP1 IIe105Val polymorphism is associated with increased LC risk in Asians.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Adenocarcinoma
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Glutationa S-Transferase pi
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Glutationa Transferase
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Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2021
Tipo de documento:
Article