Maternal separation impairs mother's cognition 1 month beyond the separation.
Int J Dev Neurosci
; 81(7): 605-615, 2021 Nov.
Article
em En
| MEDLINE
| ID: mdl-34196036
ABSTRACT
OBJECTIVE:
Separation of pups from their dam during the infancy not only has detrimental effects on the pups' brain but also affects dams' behavior. Postpartum stress may affect mothers' cognitive functions. In the present study, by using a 180-min day-1 maternal separation (MS) paradigm, we assessed anxiety-like behavior and locomotor activity of rat dams which experienced separation from postnatal day (PND) 1 until weaning. We tried for the first time to clarify whether such separation impairs dam's performance in the Morris water maze.METHOD:
We assessed dams' behavior at three time points 24 h, 1 week, and 1 month after weaning. Therefore, the six groups consisted of control (CTRL) 24 h, 1 week, and 1 month and MS 24 h, 1 week, and 1 month, which was allocated in this study.RESULTS:
Our results revealed that although MS-24 h and MS-1 week groups had intact locomotor activity, MS-1 month group showed less locomotor activity in the open field. Moreover, MS-induced anxiety-like behavior was more pronounced in MS-1 week and MS-1 month dams. Spatial learning and memory was also impaired only in MS-1 month dams.CONCLUSION:
We can conclude that MS induces cognitive impairments in dam that may appear not immediately after the separation but a few weeks after such stressful event.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Aprendizagem em Labirinto
/
Privação Materna
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Int J Dev Neurosci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Irã