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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease.
Lim, Chew Theng; Tan, Kang Wei; Wu, Mary; Ulferts, Rachel; Armstrong, Lee A; Ozono, Eiko; Drury, Lucy S; Milligan, Jennifer C; Zeisner, Theresa U; Zeng, Jingkun; Weissmann, Florian; Canal, Berta; Bineva-Todd, Ganka; Howell, Michael; O'Reilly, Nicola; Beale, Rupert; Kulathu, Yogesh; Labib, Karim; Diffley, John F X.
Afiliação
  • Lim CT; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Tan KW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Wu M; High-Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Armstrong LA; MRC Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Ozono E; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Zeisner TU; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Bineva-Todd G; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Howell M; High-Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • O'Reilly N; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Kulathu Y; MRC Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Labib K; MRC Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Biochem J ; 478(13): 2517-2531, 2021 07 16.
Article em En | MEDLINE | ID: mdl-34198325

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas / Proteases Semelhantes à Papaína de Coronavírus / SARS-CoV-2 Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals Idioma: En Revista: Biochem J Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas / Proteases Semelhantes à Papaína de Coronavírus / SARS-CoV-2 Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals Idioma: En Revista: Biochem J Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido