Catalytic asymmetric multicomponent reactions of isocyanide, isothiocyanate and alkylidene malonates.
Chem Commun (Camb)
; 57(59): 7288-7291, 2021 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-34212960
ABSTRACT
Several unique chiral 3,4-dihydro-2H-pyrrole-2-thiones were made readily available by carrying out, in each case, a chiral-Mg(OTf)2/N,N'-dioxide-complex-promoted formal [2+1+2] cycloaddition in the presence of tetraethylenediamine. Control experiments revealed that in situ-generated ammonium thiocyanate was crucial for maintaining high enantioselectivity through its inhibition of the HNCS-induced racemization of the products.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article