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Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model.
Gebert, Johannes; Gelincik, Ozkan; Oezcan-Wahlbrink, Mine; Marshall, Jason D; Hernandez-Sanchez, Alejandro; Urban, Katharina; Long, Mark; Cortes, Eduardo; Tosti, Elena; Katzenmaier, Eva-Maria; Song, Yurong; Elsaadi, Ali; Deng, Nan; Vilar, Eduardo; Fuchs, Vera; Nelius, Nina; Yuan, Yan P; Ahadova, Aysel; Sei, Shizuko; Shoemaker, Robert H; Umar, Asad; Wei, Lei; Liu, Song; Bork, Peer; Edelmann, Winfried; von Knebel Doeberitz, Magnus; Lipkin, Steven M; Kloor, Matthias.
Afiliação
  • Gebert J; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany. Electronic address: johannes.gebert@med.uni-heidelberg.de.
  • Gelincik O; Weill Cornell Medical College, New York, New York.
  • Oezcan-Wahlbrink M; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany.
  • Marshall JD; Cancer ImmunoPrevention Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Hernandez-Sanchez A; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany.
  • Urban K; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany.
  • Long M; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
  • Cortes E; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
  • Tosti E; Department of Cell Biology, Albert Einstein College of Medicine, New York, New York.
  • Katzenmaier EM; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany.
  • Song Y; Cancer ImmunoPrevention Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  • Elsaadi A; Weill Cornell Medical College, New York, New York.
  • Deng N; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Vilar E; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Fuchs V; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany.
  • Nelius N; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany.
  • Yuan YP; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany.
  • Ahadova A; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany.
  • Sei S; Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
  • Shoemaker RH; Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
  • Umar A; Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland.
  • Wei L; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
  • Liu S; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
  • Bork P; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany; Max Delbrück Centre for Molecular Medicine, Berlin, Germany; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany.
  • Edelmann W; Department of Cell Biology, Albert Einstein College of Medicine, New York, New York.
  • von Knebel Doeberitz M; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany. Electronic address: magnus.knebel-doeberitz@med.uni-heidelberg.de.
  • Lipkin SM; Weill Cornell Medical College, New York, New York. Electronic address: stl2012@med.cornell.edu.
  • Kloor M; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center, Heidelberg, Germany. Electronic address: matthias.kloor@med.uni-heidelberg.de.
Gastroenterology ; 161(4): 1288-1302.e13, 2021 10.
Article em En | MEDLINE | ID: mdl-34224739
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Neoplasias Colorretais Hereditárias sem Polipose / Mutação da Fase de Leitura / Vacinas Anticâncer / Fenômenos Imunogenéticos / Antígenos de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Gastroenterology Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Neoplasias Colorretais Hereditárias sem Polipose / Mutação da Fase de Leitura / Vacinas Anticâncer / Fenômenos Imunogenéticos / Antígenos de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Gastroenterology Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos