Antitumor properties of novel sesquiterpene lactone analogs as NF&#954;B inhibitors that bind to the IKKß ubiquitin-like domain (ULD).

Penthala, Narsimha R; Balasubramaniam, Meenakshisundaram; Dachavaram, Soma Shekar; Morris, Earl J; Bhat-Nakshatri, Poornima; Ponder, Jessica; Jordan, Craig T; Nakshatri, Harikrishna; Crooks, Peter A

Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKß ubiquitin-like domain (ULD).

Penthala, Narsimha R; Balasubramaniam, Meenakshisundaram; Dachavaram, Soma Shekar; Morris, Earl J; Bhat-Nakshatri, Poornima; Ponder, Jessica; Jordan, Craig T; Nakshatri, Harikrishna; Crooks, Peter A.

Afiliação

Penthala NR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.
Balasubramaniam M; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.
Dachavaram SS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.
Morris EJ; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.
Bhat-Nakshatri P; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, United States.
Ponder J; Division of Hematology and University of Colorado, Aurora, CO, 80045, United States.
Jordan CT; Division of Hematology and University of Colorado, Aurora, CO, 80045, United States.
Nakshatri H; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, United States.
Crooks PA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States. Electronic address: pacrooks@uams.edu.

Eur J Med Chem ; 224: 113675, 2021 Nov 15.

Article em En | MEDLINE | ID: mdl-34229108

Assuntos

Antineoplásicos/química; NF-kappa B/antagonistas & inibidores; Sesquiterpenos/química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Sítios de Ligação; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Lactonas/química; Simulação de Acoplamento Molecular; NF-kappa B/química; NF-kappa B/metabolismo; Fosforilação/efeitos dos fármacos; Domínios Proteicos; Sesquiterpenos/metabolismo; Sesquiterpenos/farmacologia; Relação Estrutura-Atividade; Termodinâmica; Fator de Transcrição RelA/metabolismo

Palavras-chave

Anticancer activity; Antileukemic activity; Benzyl and phenethyl amine; Carbamates; Melampomagnolide B

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / NF-kappa B / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: França

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