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lncRNAs as Hallmarks for Individualized Treatment of Gastric Cancer.
Wu, Jing; Xu, Shan; Li, Wei; Lu, Yuru; Zhou, Yu; Xie, Ming; Luo, Yichen; Cao, Yijing; He, Yan; Zeng, Tiebing; Ling, Hui.
Afiliação
  • Wu J; Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Xu S; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department document (Approval number: 2014-405)], Hengyang, Hunan 421001, P.R. China.
  • Li W; Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Lu Y; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department document (Approval number: 2014-405)], Hengyang, Hunan 421001, P.R. China.
  • Zhou Y; Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Xie M; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department document (Approval number: 2014-405)], Hengyang, Hunan 421001, P.R. China.
  • Luo Y; Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Cao Y; Class 15, 2018 Clinical medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
  • He Y; Shaoyang University, Shaoyang, Hunan 422000, P.R. China.
  • Zeng T; The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan 422000, P.R. China.
  • Ling H; Key Laboratory of Tumor Cellular & Molecular Pathology (University of South China), College of Hunan Province, Cancer Research Institute, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China.
Anticancer Agents Med Chem ; 22(8): 1440-1457, 2022.
Article em En | MEDLINE | ID: mdl-34229588
Gastric cancer is a global cancer with a high mortality rate. A growing number of studies have found the abnormal expression of lncRNA (long noncoding RNA) in many tumors, which plays a role in promoting or inhibiting cancer. Similarly, lncRNA abnormal expression plays an essential biological function in gastric cancer. This article focuses on lncRNA involvement in the development of gastric cancer in terms of cell cycle disorder, apoptosis inhibition, metabolic remodeling, promotion of tumor inflammation, immune escape, induction of angiogenesis, and Epithelial Mesenchymal Transition (EMT). The involvement of lncRNA in the development of gastric cancer is related to drug resistance, such as cisplatin and multi-drug resistance. It can also be used as a potential marker for the diagnosis and prognosis of gastric cancer and a target for the treatment. With an in-depth understanding of the mechanism of lncRNA in gastric cancer, new ideas for personalized treatment of gastric cancer are expected.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Anticancer Agents Med Chem Assunto da revista: ANTINEOPLASICOS / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Anticancer Agents Med Chem Assunto da revista: ANTINEOPLASICOS / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda