Pyrazole ring-containing isolongifolanone derivatives as potential CDK2 inhibitors: Evaluation of anticancer activity and investigation of action mechanism.

Wang, Yunyun; Shi, Wei; Wu, Chenliang; Wan, Lin; Zhao, Yuxun; Zhang, Chenglong; Gu, Wen; Wang, Shifa

Wang, Yunyun; Shi, Wei; Wu, Chenliang; Wan, Lin; Zhao, Yuxun; Zhang, Chenglong; Gu, Wen; Wang, Shifa.

Afiliação

Wang Y; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Shi W; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Wu C; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Wan L; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Zhao Y; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Zhang C; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Gu W; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Wang S; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address: wangshifa65@163.com.

Biomed Pharmacother ; 139: 111663, 2021 Jul.

Article em En | MEDLINE | ID: mdl-34243605

Assuntos

Antineoplásicos/farmacologia; Quinase 2 Dependente de Ciclina/metabolismo; Pirazóis/farmacologia; Sesquiterpenos/farmacologia; Células A549; Aminoácidos/metabolismo; Apoptose/efeitos dos fármacos; Caspase 3/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Regulação para Baixo/efeitos dos fármacos; Fase G1/efeitos dos fármacos; Células HeLa; Humanos; Células MCF-7; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

3D culture models; Anti-cancer activity; Apoptosis; Isolongifolanone; P53 signaling pathway; Pyrazole derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Sesquiterpenos / Quinase 2 Dependente de Ciclina / Antineoplásicos Limite: Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: França

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