Mammalian alcohol dehydrogenase: characteristics of class III isoenzymes.
Alcohol Alcohol Suppl
; 1: 169-73, 1987.
Article
em En
| MEDLINE
| ID: mdl-3426675
ABSTRACT
The kinetic characteristics of alcohol dehydrogenase class III have been studied using class III isoenzymes purified from human liver (X-ADH) and rat liver (ADH-2). Our results confirm that long chain primary alcohols and aldehydes are the best substrates, although some aromatic compounds can also be actively metabolized. Kinetic analysis suggests an ordered bibi mechanism for X-ADH. Ethanol can be oxidized by class III isoenzymes at high substrate concentration, but with a very slow rate. Thus, their contribution to physiological ethanol elimination is probably insignificant. The general properties of the class III isoenzymes isolated from different mammals by ourselves and other authors are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Álcool Desidrogenase
/
Isoenzimas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Alcohol Alcohol Suppl
Assunto da revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM