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Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting.
Bear, Adham S; Blanchard, Tatiana; Cesare, Joseph; Ford, Michael J; Richman, Lee P; Xu, Chong; Baroja, Miren L; McCuaig, Sarah; Costeas, Christina; Gabunia, Khatuna; Scholler, John; Posey, Avery D; O'Hara, Mark H; Smole, Anze; Powell, Daniel J; Garcia, Benjamin A; Vonderheide, Robert H; Linette, Gerald P; Carreno, Beatriz M.
Afiliação
  • Bear AS; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. adham.bear@pennmedicine.upenn.edu.
  • Blanchard T; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. adham.bear@pennmedicine.upenn.edu.
  • Cesare J; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Ford MJ; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
  • Richman LP; MSBioworks, Ann Arbor, MI, USA.
  • Xu C; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Baroja ML; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • McCuaig S; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Costeas C; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Gabunia K; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Scholler J; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Posey AD; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • O'Hara MH; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Smole A; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Powell DJ; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
  • Garcia BA; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Vonderheide RH; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Linette GP; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Carreno BM; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nat Commun ; 12(1): 4365, 2021 07 16.
Article em En | MEDLINE | ID: mdl-34272369
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Receptores de Antígenos de Linfócitos T alfa-beta / Linfócitos T CD8-Positivos / Epitopos de Linfócito T / Carcinogênese / Neoplasias Pulmonares Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Receptores de Antígenos de Linfócitos T alfa-beta / Linfócitos T CD8-Positivos / Epitopos de Linfócito T / Carcinogênese / Neoplasias Pulmonares Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido