Copper/Lewis base cooperatively catalyzed asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with azomethine ylides.

Hu, Yimin; Yan, Zhengyang; Shi, Wangyu; Liao, Jianning; Liu, Min; Pan, Ting; Wang, Wei; Wu, Yongjun; Hao, Xianghong; Guo, Hongchao

Hu, Yimin; Yan, Zhengyang; Shi, Wangyu; Liao, Jianning; Liu, Min; Pan, Ting; Wang, Wei; Wu, Yongjun; Hao, Xianghong; Guo, Hongchao.

Afiliação

Hu Y; Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China. hchguo@cau.edu.cn haobing4696@163.com.
Yan Z; Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China. hchguo@cau.edu.cn haobing4696@163.com.
Shi W; Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China. hchguo@cau.edu.cn haobing4696@163.com.
Liao J; Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China. hchguo@cau.edu.cn haobing4696@163.com.
Liu M; Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China. hchguo@cau.edu.cn haobing4696@163.com.
Pan T; Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China. hchguo@cau.edu.cn haobing4696@163.com.
Wang W; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Wu Y; College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Hao X; Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China. hchguo@cau.edu.cn haobing4696@163.com.
Guo H; Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China. hchguo@cau.edu.cn haobing4696@163.com.

Chem Commun (Camb) ; 57(65): 8059-8062, 2021 Aug 12.

Article em En | MEDLINE | ID: mdl-34296236

ABSTRACT

ABSTRACT

In this paper, an asymmetric allylic alkylation of easily available azomethine ylides with Morita-Baylis-Hillman (MBH) carbonates through a copper (i)/Lewis base cooperative catalysis strategy has been realized. The co-catalyzed asymmetric allylic alkylation provided the corresponding amino acid derivatives in up to 90% yields with up to 99% ee as well as good to excellent regioselectivity.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de publicação: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

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