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α-Methylacyl-CoA racemase: a useful immunohistochemical marker of breast carcinoma with apocrine differentiation.
Nakamura, Harumi; Kukita, Yoji; Kunimasa, Kei; Kittaka, Nobuyoshi; Kusama, Hiroki; Nakayama, Takahiro; Tamaki, Yasuhiro; Sugiura, Ryoko; Yasuda, Hidemitsu; Hashimoto, Masanori; Yamamoto, Takashi; Imamura, Fumio; Nakatsuka, Sin-Ichi.
Afiliação
  • Nakamura H; Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka 5418567, Japan; Department of Diagnostic Pathology, National Center for Global Health and Medicine, Tokyo 1628655, Japan; Department of Research Center, Laboratory of Genomic Pathology, Osaka International C
  • Kukita Y; Department of Research Center, Laboratory of Genomic Pathology, Osaka International Cancer Institute, Osaka 5418567, Japan.
  • Kunimasa K; Department of Oncology, Osaka International Cancer Institute, Osaka 5418567, Japan.
  • Kittaka N; Department of Surgery, Osaka International Cancer Institute, Osaka 5418567, Japan.
  • Kusama H; Department of Surgery, Osaka International Cancer Institute, Osaka 5418567, Japan.
  • Nakayama T; Department of Surgery, Osaka International Cancer Institute, Osaka 5418567, Japan.
  • Tamaki Y; Department of Surgery, Osaka International Cancer Institute, Osaka 5418567, Japan.
  • Sugiura R; Department of Surgery, National Center for Global Health and Medicine, Tokyo 1628655, Japan.
  • Yasuda H; Department of Surgery, National Center for Global Health and Medicine, Tokyo 1628655, Japan.
  • Hashimoto M; Department of Surgery, National Center for Global Health and Medicine, Tokyo 1628655, Japan.
  • Yamamoto T; Department of Clinical Laboratory, Osaka International Cancer Institute, Osaka 5418567, Japan.
  • Imamura F; Department of Oncology, Osaka International Cancer Institute, Osaka 5418567, Japan.
  • Nakatsuka SI; Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka 5418567, Japan.
Hum Pathol ; 116: 39-48, 2021 10.
Article em En | MEDLINE | ID: mdl-34314764
ABSTRACT
Carcinoma with apocrine differentiation is an androgen receptor (AR)-positive subset of triple-negative breast carcinomas. In addition to carcinoma with apocrine differentiation, other AR-positive triple-negative breast carcinomas occur, albeit less frequently. We found that α-methylacyl-CoA racemase (AMACR), also known as P504S, is overexpressed in carcinoma with apocrine differentiation and non-neoplastic apocrine metaplasia. We aimed to evaluate AMACR as a possible marker of carcinoma with apocrine differentiation. We immunohistochemically examined the expression of AMACR in carcinoma with apocrine differentiation and nonapocrine carcinomas and compared it with that of gross cystic disease fluid protein-15 (GCDFP-15). In total, 212 breast carcinomas were evaluated 39 carcinomas with apocrine differentiation, 28 ductal carcinomas in situ with apocrine morphology (ADCIS), and 145 nonapocrine breast carcinomas. AMACR was expressed in 38 of 39 (97.4%) carcinomas with apocrine differentiation and in 27 of 28 (96.4%) ADCIS, consistent with the expression of GCDFP-15. However, in nonapocrine carcinomas, AMACR expression was observed in 32 of 145 (22.0%) lesions, whereas GCDFP-15 expression was observed in 91 of 145 (62.7%) lesions. For carcinoma with apocrine differentiation, AMACR was as sensitive as GCDFP-15 (both 97.1%) but more specific (77.9% versus 37.2%). In selected cases, AMACR messenger RNA (mRNA) levels were quantitatively determined relative to that of TATA-binding protein mRNA, and they comprised 5.23, 1.33, and 0.60 for carcinomas with apocrine differentiation, nonapocrine carcinomas, and normal breast tissue, respectively.

CONCLUSION:

Our findings demonstrate that AMACR expression may be used for differentiating carcinoma with apocrine differentiation from nonapocrine carcinomas and indicate that AMACR is a more sensitive carcinoma with apocrine differentiation marker than GCDFP-15.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Biomarcadores Tumorais / Carcinoma Ductal de Mama / Racemases e Epimerases Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Hum Pathol Assunto da revista: PATOLOGIA Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Biomarcadores Tumorais / Carcinoma Ductal de Mama / Racemases e Epimerases Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Hum Pathol Assunto da revista: PATOLOGIA Ano de publicação: 2021 Tipo de documento: Article