Tomatidine provides mitophagy-independent neuroprotection after ischemic injury.

Wang, Yu-Ting; Zhang, Li-Na; Lyu, Xiao-Cui; Li, Yue; Ahsan, Anil; Feng, Zikai; Zhang, Xiangnan

Wang, Yu-Ting; Zhang, Li-Na; Lyu, Xiao-Cui; Li, Yue; Ahsan, Anil; Feng, Zikai; Zhang, Xiangnan.

Afiliação

Wang YT; Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhang LN; Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Lyu XC; Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Li Y; Institute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Ahsan A; Institute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Feng Z; Institute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Zhang X; Institute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

FEBS Open Bio ; 11(9): 2647-2654, 2021 09.

Article em En | MEDLINE | ID: mdl-34347928

Assuntos

Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Mitofagia/efeitos dos fármacos; Tomatina/análogos & derivados; Animais; Isquemia Encefálica/tratamento farmacológico; Isquemia Encefálica/etiologia; Isquemia Encefálica/metabolismo; Isquemia Encefálica/patologia; Linhagem Celular Tumoral; Sobrevivência Celular; Glucose/metabolismo; Humanos; Camundongos; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Fármacos Neuroprotetores/farmacologia; Oxigênio/metabolismo; Tomatina/farmacologia

Palavras-chave

autophagy; cerebral ischemia; mitophagy; tomatidine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tomatina / Mitofagia / Mitocôndrias Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: FEBS Open Bio Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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