Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-&#954;B Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential.

Narozna, Maria; Krajka-Kuzniak, Violetta; Bednarczyk-Cwynar, Barbara; Kucinska, Malgorzata; Kleszcz, Robert; Kujawski, Jacek; Piotrowska-Kempisty, Hanna; Plewinski, Adam; Murias, Marek; Baer-Dubowska, Wanda

Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential.

Narozna, Maria; Krajka-Kuzniak, Violetta; Bednarczyk-Cwynar, Barbara; Kucinska, Malgorzata; Kleszcz, Robert; Kujawski, Jacek; Piotrowska-Kempisty, Hanna; Plewinski, Adam; Murias, Marek; Baer-Dubowska, Wanda.

Afiliação

Narozna M; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Krajka-Kuzniak V; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Bednarczyk-Cwynar B; Department of Organic Chemistry, Poznan University of Medical Sciences, 60-780 Poznan, Poland.
Kucinska M; Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland.
Kleszcz R; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Kujawski J; Department of Organic Chemistry, Poznan University of Medical Sciences, 60-780 Poznan, Poland.
Piotrowska-Kempisty H; Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland.
Plewinski A; Centre for Advanced Technologies, Adam Mickiewicz University, 61-614 Poznan, Poland.
Murias M; Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland.
Baer-Dubowska W; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 60-781 Poznan, Poland.

Pharmaceuticals (Basel) ; 14(7)2021 Jul 17.

Article em En | MEDLINE | ID: mdl-34358114

Palavras-chave

HCC; HepG2 cells; NF-κB; NOD/SCID mice; Nrf2; THLE-2 cells; apoptosis; diclofenac; inflammation; oleanolic acid derivative conjugates; reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia País de publicação: Suíça

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