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A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging.
Wu, Mingzhou; He, Shuqing; Hu, Xin; Chen, Jingqin; Ha, Enna; Ai, Fujin; Ji, Tao; Hu, Junqing; Ruan, Shuangchen.
Afiliação
  • Wu M; Shenzhen Key Laboratory of Laser Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China.
  • He S; College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
  • Hu X; College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
  • Chen J; College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
  • Ha E; Research Laboratory for Biomedical Optics and Molecular Imaging, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
  • Ai F; College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
  • Ji T; College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
  • Hu J; College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
  • Ruan S; College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
Front Chem ; 9: 695511, 2021.
Article em En | MEDLINE | ID: mdl-34368079
ABSTRACT
Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu7.2S4/5MoS2 composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu7.2S4/5MoS2 exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal-chemodynamic-photodynamic synergetic therapeutic effect in both in vitro and in vivo tests. Moreover, Cu7.2S4/5MoS2 shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These results suggest a potential application of Cu7.2S4/5MoS2 composite nanoflowers as photo/H2O2-responsive therapeutic agents against tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China