Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation.

Ji, Changwei; Si, Jingxing; Xu, Yan; Zhang, Wenjing; Yang, Yaqian; He, Xin; Xu, Hao; Mou, Xiaozhou; Ren, Hao; Guo, Hongqian

Ji, Changwei; Si, Jingxing; Xu, Yan; Zhang, Wenjing; Yang, Yaqian; He, Xin; Xu, Hao; Mou, Xiaozhou; Ren, Hao; Guo, Hongqian.

Afiliação

Ji C; Department of Urology, Drum Tower Hospital, Medical school of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, Jiangsu, China.
Si J; Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
Xu Y; Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
Zhang W; School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Yang Y; School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
He X; School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Xu H; Department of Urology, Drum Tower Hospital, Medical school of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, Jiangsu, China.
Mou X; School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Ren H; Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
Guo H; Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.

Theranostics ; 11(17): 8587-8604, 2021.

Article em En | MEDLINE | ID: mdl-34373760

Assuntos

Sistemas de Liberação de Medicamentos/métodos; Nanomedicina Teranóstica/métodos; Terapia por Ultrassom/métodos; Animais; Linhagem Celular Tumoral; China; Humanos; Hipóxia/metabolismo; Tolerância Imunológica/efeitos dos fármacos; Tolerância Imunológica/fisiologia; Imunidade; Imunoterapia/métodos; Ativação de Macrófagos/efeitos dos fármacos; Camundongos; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/fisiologia; Nanopartículas/uso terapêutico; Óxido Nítrico/metabolismo; Óxido Nítrico/farmacologia; Oxigênio/metabolismo; Oxigênio/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Microambiente Tumoral/fisiologia; Ultrassonografia

Palavras-chave

Immune response; Mitochondria-targeted; Oxygen and nitric oxide codelivery; Reverse immunosuppression; Sonodynamic therapy

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia por Ultrassom / Sistemas de Liberação de Medicamentos / Nanomedicina Teranóstica Tipo de estudo: Diagnostic_studies Limite: Animals / Humans País/Região como assunto: Asia Idioma: En Revista: Theranostics Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Austrália

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google