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Isotretinoin for acne vulgaris - an update on adverse effects and laboratory monitoring.
Fallah, Haady; Rademaker, Marius.
Afiliação
  • Fallah H; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
  • Rademaker M; Department of Dermatology, Concord Repatriation General Hospital, Sydney, Australia.
J Dermatolog Treat ; 33(5): 2414-2424, 2022 Aug.
Article em En | MEDLINE | ID: mdl-34379039
A significant barrier to the usage of isotretinoin has been concerns regarding its adverse effect profile. The dose-dependent mucocutaneous side effects of isotretinoin are well recognized and easily managed, particularly if a lower dose is used. A possible association with depression has gained widespread media attention and is a source of concern for many patients and their carers, but data from prospective studies and recent meta-analyses have been reassuring. Furthermore, there has been much confusion amongst both patients and physicians regarding a possible association with inflammatory bowel disease, as well the ocular and rheumatological adverse effects of isotretinoin. We provide an update on the evidence surrounding the adverse effects of isotretinoin and discuss practical strategies to prevent and manage these adverse effects. We also discuss appropriate laboratory monitoring for patients taking isotretinoin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acne Vulgar / Fármacos Dermatológicos / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Dermatolog Treat Assunto da revista: DERMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acne Vulgar / Fármacos Dermatológicos / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Dermatolog Treat Assunto da revista: DERMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália País de publicação: Reino Unido