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[Modern approaches to the genetics of depression: scopes and limitations]. / Sovremennye podkhody k izucheniyu genetiki depressii: vozmozhnosti i ogranicheniya.
Kasyanov, E D; Rukavishnikov, G V; Kibitov, A A; Malyshko, L V; Neznanov, N G; Kibitov, A O; Mazo, G E.
Afiliação
  • Kasyanov ED; Bekhterev National Medical Research Center for Psychiatry and Neurology, St Petersburg, Russia.
  • Rukavishnikov GV; Saint-Petersburg State University Pirogov Clinic of High Medical Technologies, St. Petersburg, Russia.
  • Kibitov AA; Bekhterev National Medical Research Center for Psychiatry and Neurology, St Petersburg, Russia.
  • Malyshko LV; Bekhterev National Medical Research Center for Psychiatry and Neurology, St Petersburg, Russia.
  • Neznanov NG; Bekhterev National Medical Research Center for Psychiatry and Neurology, St Petersburg, Russia.
  • Kibitov AO; Bekhterev National Medical Research Center for Psychiatry and Neurology, St Petersburg, Russia.
  • Mazo GE; Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova ; 121(5. Vyp. 2): 61-66, 2021.
Article em Ru | MEDLINE | ID: mdl-34405659
Recent findings in candidate genes for depression showed significant replication failures and thus appeared irrelevant. Much of the earlier studies' limitations can be overcome by the strategy of genome-wide association studies (GWAS), which aims to identify associations between different genomic variants and phenotypic traits without pathophysiological hypotheses application. With the use of such studies, it seems possible to calculate polygenic risk scores (PRS) as a promising approach for predicting depression risk. The aim of this review is to analyze modern approaches of genetic research used to assess the risk of depression in a population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Depressão / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Humans Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Federação Russa

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Depressão / Estudo de Associação Genômica Ampla Tipo de estudo: Prognostic_studies Limite: Humans Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Federação Russa