Upconversion NaYF4:Yb3+/Er3+@silica-TPGS Bio-Nano Complexes: Synthesis, Characterization, and In Vitro Tests for Labeling Cancer Cells.
J Phys Chem B
; 125(34): 9768-9775, 2021 09 02.
Article
em En
| MEDLINE
| ID: mdl-34415749
ABSTRACT
Fluorescence imaging is an important technique used for early diagnosis and effective treatment of some incurable diseases including cancer. Herein, we report novel NaYF4Yb3+/Er3+@silica-TPGS bio-nano complexes for labeling cancer cells. The NaYF4Yb3+/Er3+ nanoparticles have been successfully synthesized via a hydrothermal route, further coated with a silica shell, and functionalized with d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS). The experimental results indicate that NaYF4Yb3+/Er3+@silica-TPGS emits stronger upconversion luminescence than NaYF4Yb3+/Er3+ under an excitation of 980 nm. More significantly, the NaYF4Yb3+/Er3+@silica-TPGS bio-nano complexes could strongly label MCF-7 breast cancer cells for in vitro experiments detected by a fluorescence microscope. On the other hand, the complex could not typically probe healthy cells, which are HEK-293A human embryonic kidney cells, under the same experimental conditions. Because of their strong upconversion luminescence, good dispersibility, and biocompatibility, NaYF4Yb3+/Er3+@silica-TPGS bio-nano complexes can be a promising candidate/probe for biomedical labeling and diagnostics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dióxido de Silício
/
Neoplasias
Tipo de estudo:
Screening_studies
Limite:
Humans
Idioma:
En
Revista:
J Phys Chem B
Assunto da revista:
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Vietnã