Role of endocrine disrupting chemicals in children's neurodevelopment.
Environ Res
; 203: 111890, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34418446
ABSTRACT
Environmental stressors, like endocrine disrupting chemicals (EDC), are considered important contributors to the increased rates of neurodevelopmental dysfunctions. Considering the cumulative research on adverse neurodevelopmental effects associated with prenatal exposure to EDC, the purpose of this study was to review the available limited literature about the effects of postnatal exposure to EDC on child neurodevelopment and behaviour. Despite widespread children's exposure to EDC, there are a limited number of epidemiological studies on the association of this exposure with neurodevelopmental disorders, in particular in the postnatal period. The available research suggests that postnatal EDC exposure is related to adverse neurobehavioral outcomes in children; however the underlying mechanisms of action remain unclear. Timing of exposure is a key factor determining potential neurodevelopmental consequences, hence studying the impact of multiple EDC co-exposure in different vulnerable life periods could guide the identification of sensitive subpopulations. Most of the reviewed studies did not take into account sex differences in the EDC effects on children neurodevelopment. We believe that the inclusion of sex in the study design should be considered as the role of EDC on children neurodevelopment are likely sex-specific and should be taken into consideration when determining susceptibility and potential mechanisms of action.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluentes Ambientais
/
Disruptores Endócrinos
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Transtornos do Neurodesenvolvimento
Tipo de estudo:
Prognostic_studies
Limite:
Child
/
Female
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Humans
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Male
/
Pregnancy
Idioma:
En
Revista:
Environ Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Espanha